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Related Experiment Videos

The thromboelastogram and circulating lupus anticoagulant.

E Confino1, A el-Roeiy, J Friberg

  • 1Department of Obstetrics and Gynecology, Mount Sinai Hospital Medical Center, Chicago, IL 60608.

The Journal of Reproductive Medicine
|April 1, 1989
PubMed
Summary
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Abnormal lupus anticoagulant (LA) and thromboelastogram (TEG) tests do not always align in predicting hypercoagulable states. Each test may identify distinct patient groups at risk for blood clots.

Area of Science:

  • Hematology
  • Clinical Chemistry

Background:

  • Abnormal lupus anticoagulant (LA) levels are linked to an increased risk of thromboembolic events.
  • Thromboelastogram (TEG) assays are proposed as standardized methods to predict hypercoagulable states.

Purpose of the Study:

  • To correlate lupus anticoagulant (LA) and thromboelastogram (TEG) assessments in women with and without abnormal LA levels.
  • To evaluate the interchangeability of LA and TEG as predictors of hypercoagulability.

Main Methods:

  • Correlated LA and TEG measurements in 46 women (controls and those with abnormal LA).
  • Included patients with conditions like endometriosis and recurrent pregnancy loss.

Main Results:

  • A low coefficient of correlation (Rho = .3282, P = .025) was observed between LA and TEG.

Related Experiment Videos

  • Seven patients with abnormal LA had normal TEG; eight with normal LA had abnormal TEG.
  • Only nine patients showed concurrent abnormalities in both LA and TEG.

    • Conclusions:

    • Lupus anticoagulant (LA) and thromboelastogram (TEG) are not interchangeable for predicting hypercoagulable states.
    • Each assay may identify different patient populations at risk for thromboembolism.