Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

New insights into Rett syndrome pathogenesis: defining the role of MEPC2 in DNA damage.

Frontiers in neurology·2026

Same author

Hmga2-dependent cAMP signaling drives UVB-induced melanocyte stem cell activation.

The Journal of investigative dermatology·2026

Same author

A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex.

Science (New York, N.Y.)·2026

Same author

Glutamine addiction is a therapeutic target to block emergency myelopoiesis.

bioRxiv : the preprint server for biology·2026

Same author

Therapy-Induced ECM Remodeling Creates a Transient Immune Barrier in Residual Melanoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Innate Immune Remodeling Drives Therapy Resistance via Macrophage-NK Cell Crosstalk.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Mar 21, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma.

William E Lowry¹, Aimee Flores², Andrew C White³

¹Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA; Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.

The Journal of Investigative Dermatology

|May 11, 2016

Summary

New methods enable inducible delivery of cancer mutations to skin cells. Hair follicle stem cells can initiate squamous cell carcinoma, with molecular factors driving tumor diversity, offering insights into Ras-driven cancer.

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Related Experiment Videos

Last Updated: Mar 21, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Area of Science:

Dermatology
Oncology
Molecular Biology

Background:

Recent advancements allow inducible delivery of oncogenic mutations to specific epidermal cell types.
Understanding the cellular origins of squamous cell carcinoma (SCC) is crucial for developing effective treatments.
Oncogenic mutations in Ras are implicated in the development of SCC.

Purpose of the Study:

To summarize findings on the role of hair follicle stem cells (HFSCs) as cancer cells of origin in SCC.
To explore how molecular players contribute to tumor cell type heterogeneity in Ras-driven SCC.
To synthesize data providing insights into Ras-initiated SCC in human patients.

Main Methods:

Utilizing inducible genetic methods to deliver oncogenic mutations to epidermal cells.
Analyzing data from laboratory experiments and published studies.
Investigating the initiation and promotion roles of specific genetic alterations.

Main Results:

Hair follicle stem cells (HFSCs) can act as the cells of origin for SCC.
Various molecular factors drive the heterogeneity observed in tumor cell types.
Specific genetic mutations can function as either tumor initiators or promoters.

Conclusions:

HFSCs are capable of initiating squamous cell carcinoma.
Molecular mechanisms contribute significantly to the diversity of SCC tumor cells.
This research offers insights into Ras-driven SCC pathogenesis and potential therapeutic strategies.