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Expression level of NSE, S100B and NPY in children with acute miliary phthisis and secondary tubercular meningitis
Insights
Elevated neuron-specific enolase (NSE), S100B, and neuropeptide Y (NPY) in cerebrospinal fluid and serum indicate secondary tubercular meningitis in children with acute miliary tuberculosis.
Area of Science:
- Pediatrics
- Neurology
- Infectious Diseases
Background:
- Acute miliary tuberculosis can lead to secondary tubercular meningitis.
- Accurate diagnosis is crucial for timely intervention.
Purpose of the Study:
- To investigate the expression levels of NSE, S100B, and NPY.
- To assess their diagnostic value in children with acute miliary tuberculosis and secondary tubercular meningitis.
Main Methods:
- Studied three groups of children: acute miliary tuberculosis with secondary meningitis, pure acute miliary tuberculosis, and suspected meningitis.
- Measured NSE, S100B, and NPY levels in cerebrospinal fluid and serum.
Main Results:
- Group A (secondary meningitis) showed significantly higher NSE, S100B, and NPY levels compared to other groups (p<0.05).
- High expression of these biomarkers correlated significantly with secondary tubercular meningitis.
Conclusions:
- Early detection of NSE, S100B, and NPY levels aids in diagnosing tubercular meningitis secondary to acute miliary tuberculosis.
- These biomarkers are valuable diagnostic indicators.
Objective:
To explore the expression level of neuron-specific enolase (NSE), S100B and neuropeptide Y (NPY) in children with acute miliary tuberculosis and secondary tubercular meningitis.
Patients And Methods:
28 children diagnosed with acute miliary tuberculosis and secondary tubercular meningitis were included into group A, 25 children diagnosed with pure acute miliary tuberculosis were included into group B and 23 children diagnosed with suspected meningitis were included into group C. The levels of NSE, S100B and NPY in cerebrospinal fluid and serum were detected.
Results:
The levels of NSE, S100B and NPY in cerebrospinal fluid and serum of group A were significantly higher than the levels in the other two groups, differences were statistically significant (p<0.05). A multifactor retrospective analysis suggested that secondary tubercular meningitis was significantly correlated with the high expression of S100B, NPY and NSE in cerebrospinal fluid and serum.
Conclusions:
Early detection of the expression levels of NSE, S100B and NPY in cerebrospinal fluid and serum was of great value for the diagnosis of tubercular meningitis secondary to acute miliary tuberculosis.
