RETRACTED: USP1 Regulates Cellular Senescence by Controlling Genomic Integrity

Area of Science:

• Biochemistry
• Molecular Biology
• Scientific Publishing Ethics

Background:

• Concerns were raised regarding the integrity of data presented in the manuscript.
• Western blot images are critical for validating experimental results in biological research.

Purpose of the Study:

• To investigate alleged data irregularities in western blots.
• To determine the extent of incorrect data use and image manipulation.
• To uphold scientific integrity and responsible research practices.

Main Methods:

• Detailed review of figures and data presented in the article.
• Analysis of western blot images for signs of manipulation, including image flipping and data reuse.
• Internal investigation by the authors to confirm the findings.

Main Results:

• Multiple instances of incorrect data use were identified across four figures.
• Specific examples include vertical flipping and panel reuse in Figures 1B and 3D.
• Further image manipulation and incorrect data application were found in Figures 2C and 4A.

Conclusions:

• The article contains significant data inaccuracies and image manipulation.
• The corresponding author takes full responsibility for the reported issues.
• Retraction of the manuscript is deemed the most responsible action to preserve scientific trust.