Related Experiment Video For Accuracy
Updated: Mar 21, 2026
Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns
Published on: August 30, 2013
Diagnostic performance of contrast-enhanced spectral mammography: Systematic review and meta-analysis
Alberto Stefano Tagliafico1, Bianca Bignotti2, Federica Rossi3
1Institute of Anatomy, Department of Experimental Medicine, University of Genoa, Via L.B. Alberti, 16132 Genoa, Italy.
Purpose:
To estimate sensitivity and specificity of CESM for breast cancer diagnosis.
Methods:
Systematic review and meta-analysis of the accuracy of CESM in finding breast cancer in highly selected women. We estimated summary receiver operating characteristic curves, sensitivity and specificity according to quality criteria with QUADAS-2.
Results:
Six hundred four studies were retrieved, 8 of these reporting on 920 patients with 994 lesions, were eligible for inclusion. Estimated sensitivity from all studies was: 0.98 (95% CI: 0.96-1.00). Specificity was estimated from six studies reporting raw data: 0.58 (95% CI: 0.38-0.77). The majority of studies were scored as at high risk of bias due to the very selected populations.
Conclusion:
CESM has a high sensitivity but very low specificity. The source studies were based on highly selected case series and prone to selection bias. High-quality studies are required to assess the accuracy of CESM in unselected cases.
Related Concept Videos
01:15Receiver Operating Characteristic Plot
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
01:24Magnetic Resonance Imaging