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Bone quality assessed using quantitative ultrasound at the distal radius does not differ in antiretroviral
E Mutimura1, Q Shi2, D R Hoover3
1Regional Alliance for Sustainable Development (RASD), Kigali, Rwanda. eugene.mutimura@gmail.com.
Objectives:
The incidence of fractures appears to be increased in HIV-infected individuals.
Methods:
We assessed bone quality using quantitative ultrasound (QUS) in HIV-infected and uninfected Rwandan women. A Sunlight Omnisense 7000 QUS was used to measure the speed of ultrasound (SOS) at the distal radius in 646 antiretroviral therapy (ART)-naïve HIV-infected women and 211 HIV-uninfected women. The Z-scores for SOS were based on data for women of the same age from the manufacturer's reference material.
Results:
The mean CD4 cell count was 285 (± 166) cells/μL in the HIV-positive women. SOS Z-scores adjusted and unadjusted for body mass index did not differ between the groups. SOS did not differ by CD4 count (< 200 vs. ≥ 200 cells/μL: 4016 (± 117) vs. 4028 (± 107) m/s, respectively; p=0.19.
Conclusions:
In HIV-positive ART-naïve Rwandan women with advanced HIV disease, bone quality at the distal radius was similar to that in HIV-negative controls.
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