Related Experiment Video

Updated: Mar 21, 2026

Analysis of Tubular Membrane Networks in Cardiac Myocytes from Atria and Ventricles
10:30

Analysis of Tubular Membrane Networks in Cardiac Myocytes from Atria and Ventricles

Published on: October 15, 2014

21.1K

TORC2 Structure and Function

Christl Gaubitz1, Manoel Prouteau1, Beata Kusmider1

  • 1Department of Molecular Biology, and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, 30 quai Ernest Ansermet, CH1211 Geneva, Switzerland.

Trends in Biochemical Sciences
|May 11, 2016
PubMed

Insights

Recent advances illuminate the target of rapamycin complex 2 (TORC2) signaling pathway. New insights into TORC2 structure and function suggest its potential as a future clinical drug target.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Cell Signaling

Background:

  • The target of rapamycin (TOR) kinase exists in two complexes: TORC1 and TORC2.
  • TORC1 signaling is well-understood and is a validated drug target for immunosuppression and oncology.
  • TORC2 signaling has remained less understood, with limited knowledge of its function and therapeutic potential.

Purpose of the Study:

  • To review recent advances in understanding TORC2 structure and function.
  • To explore the emerging potential of TORC2 as a clinical drug target.

Main Methods:

  • Review of recent structural studies of TORC1 and TORC2.
  • Analysis of data from tissue-specific mTORC2 knockout mice.
  • Discussion of novel small molecules enabling acute TORC2 inhibition.

Main Results:

  • Acute inhibition of TORC2 is now achievable with small molecules.
  • Recent structural studies have provided new insights into both TORC1 and TORC2.
  • Studies using knockout mice have helped define TORC2 structure-function relationships.

Conclusions:

  • The knowledge gap regarding TORC2 is rapidly closing.
  • Mammalian TORC2 is emerging as a potential future therapeutic target.
  • Further research into TORC2 may yield new treatments for various diseases.
Keywords:
cancerconditional knockout mouse modelcryo-electron microscopymembrane tension homeostasismetabolismsubunit conservationsubunit topologytarget of rapamycin complex 2 (TORC2)therapeutic potential

More Related Videos

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

8.7K
Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

13.5K

Related Concept Videos

ATP Synthase: Structure01:18

ATP Synthase: Structure

ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
17.1K
Cytoskeletal Accessory Proteins01:13

Cytoskeletal Accessory Proteins

The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
4.2K
Overview of Myosin Structure and Function01:15

Overview of Myosin Structure and Function

Myosins are a family of molecular motor proteins, first identified in the skeletal muscles, where they are responsible for muscle contraction. Along with their role in muscle contraction, these proteins also play a role in the intracellular transport of molecules and vesicles. There are twenty-four classes of myosins based on their domain sequence and organization. Of the twenty-four, six classes (Myosin I, Myosin II, Myosin V, Myosin VI, Myosin VII, and Myosin X)  have been well...
7.3K
Structural Protein Function01:56

Structural Protein Function

3.3K
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.4K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
7.0K