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Related Experiment Video

Updated: Mar 21, 2026

Analysis of Tubular Membrane Networks in Cardiac Myocytes from Atria and Ventricles
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TORC2 Structure and Function.

Christl Gaubitz1, Manoel Prouteau1, Beata Kusmider1

  • 1Department of Molecular Biology, and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, 30 quai Ernest Ansermet, CH1211 Geneva, Switzerland.

Trends in Biochemical Sciences
|May 11, 2016
PubMed
Summary
This summary is machine-generated.

Recent advances illuminate the target of rapamycin complex 2 (TORC2) signaling pathway. New insights into TORC2 structure and function suggest its potential as a future clinical drug target.

Keywords:
cancerconditional knockout mouse modelcryo-electron microscopymembrane tension homeostasismetabolismsubunit conservationsubunit topologytarget of rapamycin complex 2 (TORC2)therapeutic potential

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Area of Science:

  • Molecular Biology
  • Biochemistry
  • Cell Signaling

Background:

  • The target of rapamycin (TOR) kinase exists in two complexes: TORC1 and TORC2.
  • TORC1 signaling is well-understood and is a validated drug target for immunosuppression and oncology.
  • TORC2 signaling has remained less understood, with limited knowledge of its function and therapeutic potential.

Purpose of the Study:

  • To review recent advances in understanding TORC2 structure and function.
  • To explore the emerging potential of TORC2 as a clinical drug target.

Main Methods:

  • Review of recent structural studies of TORC1 and TORC2.
  • Analysis of data from tissue-specific mTORC2 knockout mice.
  • Discussion of novel small molecules enabling acute TORC2 inhibition.

Main Results:

  • Acute inhibition of TORC2 is now achievable with small molecules.
  • Recent structural studies have provided new insights into both TORC1 and TORC2.
  • Studies using knockout mice have helped define TORC2 structure-function relationships.

Conclusions:

  • The knowledge gap regarding TORC2 is rapidly closing.
  • Mammalian TORC2 is emerging as a potential future therapeutic target.
  • Further research into TORC2 may yield new treatments for various diseases.