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Liquid crystals based sensing platform-technological aspects.

Zakir Hussain1, Farah Qazi1, Muhammad Imran Ahmed1

  • 1School of Chemical and Materials Engineering (SCME), National University of Sciences & Technology (NUST), Sector H-12, 44000 Islamabad, Pakistan.

Biosensors & Bioelectronics
|May 11, 2016
PubMed
Summary

Liquid crystals, sensitive to external stimuli, enable optical sensing of biological interactions and analytes. This review overviews current liquid crystal sensing schemes, their limitations, and potential material improvements.

Keywords:
Biomolecular assembliesBiosensorsDetectionLiquid crystalsToxic chemicals

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Area of Science:

  • Materials Science
  • Biophysics
  • Analytical Chemistry

Background:

  • Liquid crystals exhibit molecular organization driven by non-covalent interactions, making them sensitive to external stimuli.
  • This sensitivity is the foundation for liquid crystal-based sensing platforms used for optical visualization and analyte detection.
  • Existing liquid crystal sensing schemes have demonstrated utility in detecting biological interactions and various analytes.

Purpose of the Study:

  • To provide a comprehensive overview of the current state-of-the-art in liquid crystal-based sensing.
  • To critically evaluate the limitations inherent in current liquid crystal sensing platforms.
  • To explore potential materials and approaches for enhancing the performance and technological integration of these sensing schemes.

Main Methods:

  • Review of existing literature on liquid crystal sensing platforms.
  • Analysis of key components including substrates, alignment layers, liquid crystal types, and interfaces.
  • Identification of limitations and areas for improvement in sensing performance and material science.

Main Results:

  • Liquid crystal organization is delicate and easily disrupted by external stimuli, forming the basis for sensing.
  • Current sensing schemes are effective for optical visualization and detection of biological interactions and analytes.
  • Limitations exist in various components of the sensing platform, including substrates, alignment layers, and interfaces.

Conclusions:

  • Liquid crystal-based sensing offers a versatile platform for optical detection.
  • Addressing limitations in platform components and exploring novel materials can significantly improve sensing performance.
  • Bridging the gap between liquid crystal science and technological application is crucial for future advancements.