Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormonal changes in major depressive disorder.

T Kitamura, S Kano, S Shima

    The Keio Journal of Medicine
    |March 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    On the adsorption and reactivity of element 114, flerovium.

    Frontiers in chemistry·2022
    Same author

    Multifaceted array-based keloidal gene expression profiling reveals specific MDFI upregulation in keloid lesions.

    Clinical and experimental dermatology·2021
    Same author

    Study of charged particle activation analysis (II): Determination of boron concentration in human blood samples.

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2020
    Same author

    Preliminary results in using Deep Learning to emulate BLOB, a nuclear interaction model.

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2020
    Same author

    Preliminary results coupling "Stochastic Mean Field" and "Boltzmann-Langevin One Body" models with Geant4.

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2019
    Same author

    Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice.

    Molecular psychiatry·2016
    Same journal

    Transcript of the Commemorative Lecture by Dr. Akiko Iwasaki (30th Keio Medical Science Prize Award Ceremony).

    The Keio journal of medicine·2026
    Same journal

    Association of Loneliness and Health Literacy with Overuse of Over-the-counter Drugs in Patients with COVID-19 in Japan.

    The Keio journal of medicine·2026
    Same journal

    Ligustilide Attenuates Neuroinflammation and Fibrosis in an Aluminum Chloride-induced Rat Model of Alzheimer's Disease via mTOR/STAT3 Signaling Inhibition.

    The Keio journal of medicine·2026
    Same journal

    Community Pharmacists' Attitudes and Experiences Regarding the Promotion of Vaccinations in Japan.

    The Keio journal of medicine·2026
    Same journal

    Identifying High-Cost RSV Hospitalizations at a Secondary Hospital in Japan.

    The Keio journal of medicine·2026
    Same journal

    Comparison of Clinical Development of Digital Therapeutics among Japan, the Unites States, and Germany.

    The Keio journal of medicine·2025
    See all related articles

    The dexamethasone suppression test (DST) showed the cortisol index was barely useful for discriminating depression. This index correlated with incapacitating depression symptoms, including depressed mood and psychic anxiety.

    Area of Science:

    • Endocrinology
    • Psychiatry
    • Neuroscience

    Background:

    • The dexamethasone suppression test (DST) is a diagnostic tool used in psychiatry.
    • Hormonal imbalances are implicated in depressive disorders.

    Purpose of the Study:

    • To evaluate the utility of the DST and other hormonal markers in discriminating depression.
    • To explore correlations between hormonal indices and depressive symptoms.

    Main Methods:

    • The dexamethasone suppression test (DST) was administered to 38 patients meeting Research Diagnostic Criteria (RDC) for depression.
    • Cortisol, human growth hormone (hGH), prolactin, triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) levels were measured before and after DST.
    • Cortisol index (pre-DST/post-DST cortisol ratio) was calculated.

    Related Experiment Videos

    Main Results:

    • The cortisol index demonstrated limited utility in discriminating depression.
    • A significant correlation was observed between the cortisol index and the RDC incapacitating subcategory.
    • The cortisol index also correlated with specific affective symptoms, such as depressed mood and psychic anxiety.

    Conclusions:

    • The DST, specifically the cortisol index, has minimal diagnostic value for depression.
    • The cortisol index may serve as a potential biomarker for the severity of depression and associated symptoms.