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Updated: Mar 21, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
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Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

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[Anti-cancer agents nephrotoxicity]

Mariusz Mieczkowski1, Joanna Matuszkiewicz-Rowińska1, Małgorzata Kościelska1

  • 1Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych, Warszawski Uniwersytet Medyczny, Warszawa.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|May 11, 2016
PubMed

Insights

Chemotherapy can cause various kidney injuries, including tubular damage and podocytopathies. This article summarizes the diagnosis, treatment, and prevention of these chemotherapy-induced nephrotoxicities.

Area of Science:

  • Nephrology
  • Oncology
  • Pharmacology

Context:

  • Chemotherapy is a cornerstone of cancer treatment.
  • Nephrotoxicity is a significant and common adverse effect of anti-cancer drugs.
  • Understanding chemotherapy-induced kidney injury is crucial for patient management.

Purpose:

  • To provide a concise overview of chemotherapy-induced nephrotoxicity.
  • To summarize the diverse forms of kidney injury caused by anti-cancer agents.
  • To outline diagnostic, therapeutic, and preventive strategies for managing these conditions.

Summary:

  • Chemotherapy can lead to acute and chronic tubular injuries, podocytopathies, crystal nephropathies, thrombotic microangiopathy, and electrolyte wasting syndromes.
  • The article covers the pathological changes associated with these conditions.
  • Key aspects of diagnosis, treatment, and prevention are discussed.

Impact:

  • Improved clinical recognition and management of chemotherapy-related kidney problems.
  • Enhanced patient outcomes through timely intervention and prophylaxis.
  • Foundation for further research into mitigating anti-cancer drug nephrotoxicity.

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