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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Long Non-coding RNAs in the Cytoplasm.

Farooq Rashid1, Abdullah Shah1, Ge Shan1

  • 1CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.

Genomics, Proteomics & Bioinformatics
|May 11, 2016
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) in the cytoplasm regulate gene expression through various mechanisms. This review highlights their roles in mRNA stability, translation, and as competing endogenous RNAs, offering future research perspectives.

Keywords:
MicroRNAceRNAlncRNAmRNA stabilitymRNA translation

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Long non-coding RNAs (lncRNAs) are transcribed from eukaryotic genomes and regulate cellular events.
  • Many lncRNAs function within the cytoplasm, playing critical roles in cellular processes.

Purpose of the Study:

  • To review the functions and molecular mechanisms of cytoplasmic lncRNAs.
  • To highlight key examples of cytoplasmic lncRNAs and their roles.

Main Methods:

  • Literature review of studies on cytoplasmic lncRNAs.
  • Analysis of molecular mechanisms underlying lncRNA functions.

Main Results:

  • Cytoplasmic lncRNAs modulate mRNA stability and translation.
  • lncRNAs act as competing endogenous RNAs (ceRNAs) and microRNA precursors.
  • They also mediate protein modifications.

Conclusions:

  • Cytoplasmic lncRNAs are crucial regulators of gene expression with diverse molecular functions.
  • Further research into cytoplasmic lncRNA mechanisms and applications is warranted.