Related Experiment Video
Updated: Mar 21, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Analysing the concept of diagnostic inertia in hypertension: a cross-sectional study
V Pallares-Carratalá1,2, I Bonig-Trigueros3, A Palazón-Bru4,5
1Health Surveillance Department, Mutual Society of Castellón, Castellón, Spain.
Insights
Diagnostic inertia, the failure to diagnose hypertension, affects 13.3% of patients. Key factors include male gender and older age, while conditions like atrial fibrillation and cardiovascular disease reduce its likelihood.
Area of Science:
- Cardiology
- Clinical Research
- Public Health
Background:
- Hypertension diagnosis requires timely intervention.
- Diagnostic inertia (DI) is the failure to diagnose hypertension despite elevated blood pressure readings.
- Understanding DI's prevalence and associated factors is crucial for improving patient outcomes.
Purpose of the Study:
- To quantify the prevalence of diagnostic inertia in patients with hypertension.
- To identify factors associated with diagnostic inertia in clinical practice.
Main Methods:
- A cross-sectional, observational study of 48,605 patients with at least three blood pressure measurements.
- Diagnostic inertia was defined as mean blood pressure ≥ 140/90 mmHg without a hypertension diagnosis.
- Multivariate logistic regression analyzed associations with gender, comorbidities, and physician training (ESCARVAL).
Main Results:
- Diagnostic inertia was observed in 13.3% of the study population.
- Factors associated with DI included male gender (OR=1.46) and older age.
- Atrial fibrillation (OR=0.73), cardiovascular disease (OR=0.77), and ESCARVAL training (OR=0.88) were associated with lower DI.
- The predictive model demonstrated strong performance (AUC=0.81).
Conclusions:
- Diagnostic inertia is a prevalent issue in hypertension management.
- Predictive factors for DI were identified, aiding in risk stratification.
- Further research can differentiate DI types, improving diagnostic accuracy and patient care.
Aims:
The aim of this study was to quantify diagnostic inertia (DI) when the physician fails to diagnose hypertension and determine its associated factors.
Methods:
This cross-sectional, observational study involved all patients without a diagnosis of hypertension who had their blood pressure (BP) measured at least three times during the second half of 2010 (N = 48,605). Patients with altered mean BP figures (≥ 140/90 mmHg) were considered to experience DI. Secondary variables: gender, atrial fibrillation, diabetes mellitus, dyslipidemia, cardiovascular disease, age and the physician having attended a cardiovascular training course (ESCARVAL). Associated factors were assessed by multivariate logistic regression analysis.
Results:
Diagnostic inertia was present in 6450 patients (13.3%, 95% CI: 13.0-13.6%). Factors significantly associated with DI were: male gender (OR = 1.46, 95% CI: 1.37-1.55, p < 0.001), atrial fibrillation (OR = 0.73, 95% CI: 0.58-0.92, p = 0.007), the ESCARVAL cardiovascular course (OR = 0.88, 95% CI: 0.81-0.96, p = 0.005), diabetes mellitus (OR = 0.93, 95% CI: 0.87-0.99, p = 0.016), cardiovascular disease (OR = 0.77, 95% CI: 0.67-0.88, p < 0.001) and older age (years) (18-44→OR = 1; 45-59→OR = 12.45, 95% CI: 11.11-13.94; 60-74→OR = 18.11, 95% CI: 16.30-20.12; ≥ 75→OR = 20.43, 95% CI: 18.34-22.75; p < 0.001). The multivariate model had an area under the ROC curve of 0.81 (95% CI: 0.80-0.81, p < 0.001).
Conclusions:
This study will help clinical researchers differentiate between the two forms of DI (interpretation of a positive screening test and interpretation of positive diagnostic criteria). The results found here in patients with hypertension suggest that this problem is prevalent, and that a set of associated factors can explain the outcome well (AUC>0.80).
Related Concept Videos
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension I: Introduction
Hypertension and Regulation of Blood Pressure
Errors occurring during blood pressure monitoring
Several factors...
Hypertension II: Pathophysiology
Assessment of blood pressure in brachial artery(two-step method)

