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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

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Published on: January 11, 2020

Mini-Mental State Examination in Elderly Chinese: A Population-Based Normative Study.

Hanzhi Li¹, Jianping Jia^1,2,3,4, Zhiqiang Yang¹

¹Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, P.R. China.

Journal of Alzheimer'S Disease : JAD

|May 11, 2016

Summary

Nationwide norms for the Mini-Mental State Examination (MMSE) in Chinese elderly were established, considering age, gender, education, and residence. These demographic-stratified norms improve dementia screening accuracy in this population.

Keywords:

Dementia Mini-Mental State Examination elderly mild cognitive impairment

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Area of Science:

Gerontology
Neuroscience
Public Health

Background:

The Mini-Mental State Examination (MMSE) is widely used in China for cognitive assessment.
Nationwide normative data for the MMSE are lacking, hindering accurate interpretation in diverse elderly populations.

Purpose of the Study:

To establish age-, gender-, education-, and residence-specific norms for the MMSE in the elderly Chinese population.
To determine optimal MMSE cut-off points for dementia screening.

Main Methods:

A large-scale, cross-sectional study involving 9,629 community-dwelling Chinese residents aged 65 and over.
Cluster random sampling was employed, with MMSE administration and demographic data collection.
Receiver operating characteristic (ROC) analysis was used to identify optimal cut-off points.

Main Results:

Significant demographic influences on MMSE scores included years of education, rural residence, age, and gender.
Demographic-stratified normative data for the MMSE were successfully established.
Optimal dementia screening cut-off points varied by educational attainment, ranging from 16/17 for illiterate individuals to 23/24 for those with higher education.

Conclusions:

This study provides essential, demographic-stratified MMSE reference norms for the Chinese elderly.
These norms represent a significant improvement for accurate dementia screening in this population.
The findings will enhance the clinical utility of the MMSE in China.