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Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs
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Interaction between Mesenchymal Stem Cells and B-Cells

Linxiao Fan1, Chenxia Hu2, Jiajia Chen3

  • 1Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China. 21418049@zju.edu.cn.

International Journal of Molecular Sciences
|May 11, 2016
PubMed

Mesenchymal stem cells (MSCs) are multipotent; non-hematopoietic stem cells. Because of their immunoregulatory abilities; MSCs are widely used for different clinical applications. Compared with that of other immune cells; the investigation of how MSCs specifically regulate B-cells has been superficial and insufficient. In addition; the few experimental studies on this regulation are often contradictory. In this review; we summarize the various interactions between different types or states of MSCs and B-cells; address how different types of MSCs and B-cells affect this interaction and examine how other immune cells influence the regulation of B-cells by MSCs. Finally; we hypothesize why there are conflicting results on the interaction between MSCs and B-cells in the literature.

Keywords:
B-cellT-cellcytokinegraft-versus-host diseaseimmune regulationimmune suppressionmesenchymal stem cellplasma cellsystemic lupus erythematous

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