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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
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Related Experiment Video

Updated: Mar 21, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
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BrucellaBase: Genome information resource.

Jagadesan Sankarasubramanian1, Udayakumar S Vishnu1, L K M Abdul Khader1

  • 1Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai - 625021, Tamil Nadu, India.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|May 11, 2016
PubMed
Summary
This summary is machine-generated.

BrucellaBase is a new online platform offering genome data and analysis tools for Brucella species, aiding researchers in understanding this zoonotic pathogen. It provides multilocus sequence typing and phylogenetic analysis for 510 Brucella strains.

Keywords:
BLASTBrucellaBaseCARDMLSTPhylogenyVFDB

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Area of Science:

  • Microbiology
  • Bioinformatics
  • Genomics

Background:

  • Brucella species are significant zoonotic pathogens responsible for brucellosis.
  • Brucella belongs to the Brucellaceae family within the Alphaproteobacteria class.
  • Effective tools are needed for analyzing Brucella genome data.

Purpose of the Study:

  • To introduce BrucellaBase, a comprehensive web-based platform for Brucella genome data analysis.
  • To provide researchers with integrated genome database features and unique analytical tools.

Main Methods:

  • Development of a web-based platform integrating genome data and analysis tools.
  • Implementation of web versions for multilocus sequence typing (MLST) and phylogenetic analysis.
  • Inclusion of BLAST, VFDB, CARD, and pairwise genome alignment functionalities.

Main Results:

  • BrucellaBase hosts genome data for 510 Brucella strains.
  • The platform offers user-friendly interfaces for various analytical tools.
  • Facilitates meaningful interpretation of Brucella genome sequences.

Conclusions:

  • BrucellaBase serves as a valuable resource for researchers studying Brucella.
  • The platform will be regularly updated with new data and features.
  • Enhances research capabilities in understanding Brucella pathogenesis and evolution.