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Published on: April 7, 2023
Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing
Mohammed Maniruzzaman1, Smirna Farias2, Ian J Slipper2
1Department of Pharmacy (Chemistry), School of Life Sciences, University of Sussex, Brighton, UK.
Objectives:
The aim of this study was to develop mucoadhesive oral strips using hot-melt extrusion as a continuous manufacturing process.
Methods:
Powder blends of ketoconazole, a water-insoluble drug - either hydroxypropyl methylcellulose (HPMC) or soluplus (SOL), sorbitol (SRB) and magnesium aluminometasilicate (MAS) were extruded to manufacture thin strips with 0.5-mm thickness. The presence of the inorganic metasilicate facilitated smooth processing of the extruded strips as it worked as an absorbent directly impacting on the extensive mixing of the drug/excipients inside the extruder barrel.
Key Findings:
The use of MAS also favoured the rapid hydration, swelling and eventual disintegration of the strips. Differential scanning calorimetry and transmission X-ray diffraction analysis revealed the existence of the amorphous drug within the extruded strips. Scanning electron microscopy and energy dispersive X-ray undertaken on the formulations showed a homogeneous drug distribution within the extruded strips.
Conclusion:
The strips produced via continuous hot-melt extrusion processing showed significantly faster release of ketoconazole compared to the bulk drug substance.
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