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Related Experiment Video

Updated: Mar 21, 2026

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
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Antidepressant use and circulating prolactin levels.

Katherine W Reeves1, Olivia I Okereke2,3,4, Jing Qian5

  • 1Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, 411 Arnold House, 715 North Pleasant Street, Amherst, MA, 01003, USA. kwreeves@schoolph.umass.edu.

Cancer Causes & Control : CCC
|May 12, 2016
PubMed
Summary
This summary is machine-generated.

Antidepressant use, including SSRIs, does not appear to significantly elevate prolactin levels in women. This study suggests antidepressants may not impact prolactin and potentially breast cancer risk through this mechanism.

Keywords:
AntidepressantsProlactinSelective serotonin reuptake inhibitorsWomen

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Area of Science:

  • Endocrinology
  • Psychopharmacology
  • Women's Health

Background:

  • Elevated prolactin levels can be associated with certain health risks, including potential impacts on breast cancer risk.
  • Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), are widely prescribed, making their potential endocrine effects a relevant area of study.

Purpose of the Study:

  • To investigate the association between antidepressant (AD) use, specifically SSRIs, and circulating prolactin levels in a large cohort of women.
  • To determine if AD use influences prolactin levels, which could have implications for conditions like breast cancer.

Main Methods:

  • Analysis of prolactin levels in 4593 participants from the Nurses' Health Study (NHS) and NHS2, with 267 users of antidepressants.
  • Generalized linear models and multivariable logistic regression were used to compare prolactin levels and odds of elevated prolactin between AD users and non-users.
  • Longitudinal analysis assessed changes in prolactin levels over time in relation to AD use patterns.

Main Results:

  • Adjusted mean prolactin levels were comparable across SSRI users, other AD users, and non-users.
  • Antidepressant use (OR 1.17) and SSRI use (OR 0.95) were not significantly associated with elevated prolactin levels (>11 ng/mL).
  • No significant differences in prolactin level changes were observed based on antidepressant use initiation, cessation, or consistent use.

Conclusions:

  • The study does not support the hypothesis that antidepressant use increases breast cancer risk through elevated prolactin levels.
  • Current evidence suggests that antidepressant use for depression or other conditions is unlikely to substantially increase prolactin levels in most women.