Related Experiment Video
Updated: Mar 21, 2026
08:44
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
2.9K
Precursor B cell lymphoblastic lymphoma presenting as periorbital swelling
Niamh Galway1, Robert Johnston2, Carole Cairns2
1Royal Belfast Hospital for Sick Children, Belfast, UK.
BMJ Case Reports
|May 12, 2016
Summary
A young girl presented with swelling and headache, found to have B cell lymphoblastic lymphoma. Early diagnosis and treatment via the UKALL 2011 chemotherapy trial were initiated.
Area of Science:
- Pediatric Oncology
- Ophthalmology
- Hematology
Background:
- B cell lymphoblastic lymphoma is a rare and aggressive form of non-Hodgkin lymphoma.
- Orbital and periorbital swelling can be presenting symptoms of systemic disease in children.
Observation:
- An 11-year-old girl presented with bilateral papilledema, periorbital swelling, headache, and unilateral groin swelling.
- Imaging revealed soft tissue masses in the orbits and extensive lymphadenopathy.
- Bone marrow studies were normal, but lymph node biopsy confirmed B cell lymphoblastic lymphoma.
Findings:
- Histological confirmation of B cell lymphoblastic lymphoma.
- Absence of bone marrow involvement at diagnosis.
- Extensive lymphadenopathy detected above and below the diaphragm.
Implications:
- Highlights the importance of thorough investigation for orbital and systemic symptoms in pediatric patients.
- Underscores the role of imaging and biopsy in diagnosing rare pediatric malignancies.
- Emphasizes prompt initiation of chemotherapy through clinical trials for improved outcomes.
Related Concept Videos
01:23Cells of the Adaptive Immune Response
9.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.9K
01:16Primary Lymphoid Organs
16.5K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.5K
01:15Secondary Lymphoid Organs
10.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.2K
01:24B Cell Activation and Differentiation
17.9K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.9K