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Related Experiment Video

Updated: Mar 21, 2026

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Histotripsy Thrombolysis on Retracted Clots.

Xi Zhang¹, Gabe E Owens², Charles A Cain¹

¹Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Ultrasound in Medicine & Biology

|May 12, 2016

Summary

Microtripsy, a novel ultrasound technique, effectively breaks down resistant blood clots. Enhancing this method with electronic focal steering significantly improves clot removal and restores blood flow, offering a promising drug-free treatment option.

Keywords:

Histotripsy Retracted clot Sonothrombolysis Thrombolysis Tissue elasticity

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Published on: November 26, 2013

Area of Science:

Biomedical Engineering
Ultrasound Technology
Cardiovascular Research

Background:

Retracted blood clots are notoriously resistant to conventional drug-based thrombolysis.
Existing ultrasound and microbubble methods show limited efficacy on such clots.
Traditional histotripsy approaches carry a risk of vessel damage.

Purpose of the Study:

To investigate microtripsy, a novel histotripsy approach, for non-invasive, drug-free clot dissolution.
To evaluate the efficacy of microtripsy on retracted blood clots.
To determine if electronic focal steering enhances microtripsy treatment outcomes.

Main Methods:

Retracted blood clots were created and mechanically characterized in vitro.
Microtripsy thrombolysis was applied using single-focus, multi-focus, and dual-pass strategies with electronic focal steering.
Recanalization and flow restoration were assessed in an in vitro flow model.

Main Results:

Microtripsy successfully created a flow channel through retracted clots, restoring blood flow.
Electronically-steered multi-focus and dual-pass treatments significantly increased recanalization compared to single-focus.
Dual-pass treatments achieved high flow rates (up to 324 mL/min) without vessel wall damage; debris remained within safe limits.

Conclusions:

Microtripsy is a viable non-invasive method for breaking down retracted blood clots.
Electronic focal steering significantly enhances the effectiveness of microtripsy thrombolysis.
This approach holds potential for improved retracted clot recanalization with reduced risk.