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Medication Regimen Complexity and Adherence in Haemodialysis Patients: An Exploratory Study
Saurav Ghimire1, Gregory M Peterson, Ronald L Castelino
1Unit for Medication Outcomes Research and Education (UMORE), Pharmacy, University of Tasmania, Hobart, Australia.
American Journal of Nephrology
|May 12, 2016
Summary
Older hemodialysis patients with complex medication regimens and high comorbidity are more likely to adhere to their treatment, according to objective measures. This finding highlights the importance of considering patient factors in medication management.
Area of Science:
- Nephrology
- Pharmacology
- Patient Adherence Research
Background:
- Medication regimen complexity's impact on hemodialysis patient adherence is not well understood.
- Investigated medication complexity, perceived burden of medicines (PBM), and health-related quality of life (HR-QoL) as adherence predictors.
Purpose of the Study:
- To explore the relationship between medication regimen complexity, PBM, HR-QoL, and adherence in hemodialysis patients.
- To identify predictors of medication adherence in this population.
Main Methods:
- Adult hemodialysis patients were enrolled.
- Data collected included medication regimen complexity index (MRCI), self-reported and objective adherence, comorbidity index, PBM, and HR-QoL.
- Logistic regression was used to determine adherence predictors.
Main Results:
- A total of 53 patients participated (75% response rate).
- Objective adherence (27.3%) was lower than self-reported adherence (43.4%).
- Older age, higher comorbidity, and higher MRCI independently predicted objective adherence.
Conclusions:
- Older patients with high comorbidities and complex regimens showed higher objective adherence.
- Future research should utilize objective adherence measures applicable to all patients and all medications.
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