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Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells
Shubhanchi Nigam1, Benjamin P Burke1, Laura H Davies2
1Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. S.J.Archibald@Hull.ac.uk and Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
Chemical Communications (Cambridge, England)
|May 12, 2016
Abstract:
The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.
