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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis, characterization and biological evaluation of some 5-methylpyrazine carbohydrazide based hydrazones
Mushtaq Ahmad1, Shahid Hameed2, Muhammad Nawaz Tahir3
1Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan / Medicinal Botanic Centre, PCSIR Laboratories Complex, Peshawar, Pakistan.
Abstract:
Pyrazine carbohydrazide based hydrazones were synthesized starting from 5-methylpyrazine-2-carboxylic acid. The acid was first converted to its methyl ester, which on further treatment with hydrazine hydrate transformed to carbohydrazide. The carbohydrazide was treated with differently substituted aromatic carbonyl compounds giving hydrazones. Characterization of the synthesized compounds was carried out using modern spectroscopic techniques and unambiguously confirmed through X-ray crystallographic studies of compound 3d. The purity of the compounds was verified using elemental analysis. The target molecules were evaluated for urease inhibition, antioxidant and antimicrobial activity.
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