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Updated: Mar 21, 2026

Measuring Pressure Volume Loops in the Mouse
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Measuring Pressure Volume Loops in the Mouse

Published on: May 2, 2016

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Measuring Pressure Volume Loops in the Mouse.

DeWayne Townsend1

  • 1Department of Integrative Biology and Physiology, University of Minnesota; town0045@umn.edu.

Journal of Visualized Experiments : Jove
|May 12, 2016
PubMed
Summary
This summary is machine-generated.

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This study details a precise method for collecting mouse cardiac pressure-volume loop data. This technique enhances understanding of heart disease by providing detailed cardiac function insights.

Area of Science:

  • Cardiovascular Research
  • Animal Models in Medicine
  • Biomedical Engineering

Background:

  • Heart disease research faces challenges in understanding its causes and progression.
  • Mice offer genetic flexibility for studying cardiac function at the molecular level.
  • Small animal size poses difficulties for detailed cardiac phenotyping.

Purpose of the Study:

  • To describe a detailed procedure for collecting pressure-volume (PV) loop data in mice.
  • To highlight the importance of PV loop data for a comprehensive view of cardiac function.
  • To address challenges in mouse cardiac phenotyping through technological advancements.

Main Methods:

  • Detailed procedure for collecting pressure-volume loop data in mice.
  • Discussion of underlying measurement principles and potential error sources.

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Related Experiment Videos

Last Updated: Mar 21, 2026

Measuring Pressure Volume Loops in the Mouse
09:15

Measuring Pressure Volume Loops in the Mouse

Published on: May 2, 2016

17.1K
Measurement of the Pressure-volume Curve in Mouse Lungs
09:49

Measurement of the Pressure-volume Curve in Mouse Lungs

Published on: January 27, 2015

19.6K
Measuring Blood Pressure in Mice using Volume Pressure Recording, a Tail-cuff Method
08:54

Measuring Blood Pressure in Mice using Volume Pressure Recording, a Tail-cuff Method

Published on: May 15, 2009

53.6K
  • Emphasis on anesthetic management and surgical techniques for high-quality hemodynamic measurements.

    • Main Results:

    • Simultaneous collection of pressure and volume data offers a unique, detailed picture of cardiac function.
    • The described procedure enables high-quality hemodynamic measurements in mice.
    • Anesthetic and surgical protocols are critical for accurate data acquisition.

    Conclusions:

    • The described method provides a robust approach for mouse cardiac phenotyping.
    • Accurate hemodynamic data collection is crucial for advancing heart disease research.
    • Technological advancements facilitate detailed cardiac assessment in small animal models.