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Updated: Mar 21, 2026
09:35
A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
Published on: July 16, 2016
11.7K
ERRγ-A New Player in β Cell Maturation.
Jun Shirakawa1, Rohit N Kulkarni2
1Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Cell Metabolism
|May 12, 2016
Summary
Estrogen-related receptor gamma (ERRγ) drives the functional maturation of pancreatic beta cells. This process is crucial for proper insulin secretion in both neonatal mice and human cells.
Area of Science:
- Endocrinology
- Cell Biology
- Metabolism
Background:
- Pancreatic beta cell responsiveness to glucose and hormones develops postnatally.
- This maturation is essential for regulated insulin secretion.
Purpose of the Study:
- To investigate the role of estrogen-related receptor gamma (ERRγ) in beta cell maturation.
- To determine if ERRγ influences functional development in neonatal mouse and human beta-like cells.
Main Methods:
- Utilized mouse models and human induced pluripotent stem cell-derived beta-like cells.
- Assessed functional maturation and responsiveness following ERRγ manipulation.
Main Results:
- Estrogen-related receptor gamma (ERRγ) was found to promote functional maturation.
- ERRγ enhanced glucose and hormone responsiveness in neonatal mouse beta cells.
- ERRγ also promoted maturation in human iPSC-derived beta-like cells.
Conclusions:
- Estrogen-related receptor gamma (ERRγ) is a key regulator of pancreatic beta cell functional maturation.
- Targeting ERRγ may offer therapeutic strategies for improving insulin secretion and managing metabolic disorders.
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