Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.9K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.9K
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

7.3K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
7.3K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.8K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.8K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.9K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.9K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

3.0K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
3.0K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.6K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long QT syndrome and hypoglycemia in a postbariatric surgery patient with a likely pathogenic variant in <i>KCNE1</i>.

JCEM case reports·2026
Same author

Insulin/IGF signaling in islet biology and its therapeutic implications.

Endocrine reviews·2026
Same author

Diabetes and Vitiligo.

Diabetes care·2026
Same author

Metformin suppresses β-cell apoptosis under ER stress by inhibiting protein translation.

Metabolism: clinical and experimental·2026
Same author

Proteomic analyses of human islets reveal potential markers of β cell dysfunction during prediabetes.

JCI insight·2026
Same author

Characterization of extracellular and membrane potentials in imeglimin-treated islets.

Journal of diabetes investigation·2026

Related Experiment Video

Updated: Mar 21, 2026

A High-content In Vitro Pancreatic Islet &#946;-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.7K

ERRγ-A New Player in β Cell Maturation.

Jun Shirakawa1, Rohit N Kulkarni2

  • 1Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.

Cell Metabolism
|May 12, 2016
PubMed
Summary
This summary is machine-generated.

Estrogen-related receptor gamma (ERRγ) drives the functional maturation of pancreatic beta cells. This process is crucial for proper insulin secretion in both neonatal mice and human cells.

More Related Videos

Author Spotlight: Advancements and Challenges in &#946;-Cells Differentiation from Pluripotent Stem Cells
06:33

Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells

Published on: February 2, 2024

2.8K
High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

13.1K

Related Experiment Videos

Last Updated: Mar 21, 2026

A High-content In Vitro Pancreatic Islet &#946;-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.7K
Author Spotlight: Advancements and Challenges in &#946;-Cells Differentiation from Pluripotent Stem Cells
06:33

Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells

Published on: February 2, 2024

2.8K
High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

13.1K

Area of Science:

  • Endocrinology
  • Cell Biology
  • Metabolism

Background:

  • Pancreatic beta cell responsiveness to glucose and hormones develops postnatally.
  • This maturation is essential for regulated insulin secretion.

Purpose of the Study:

  • To investigate the role of estrogen-related receptor gamma (ERRγ) in beta cell maturation.
  • To determine if ERRγ influences functional development in neonatal mouse and human beta-like cells.

Main Methods:

  • Utilized mouse models and human induced pluripotent stem cell-derived beta-like cells.
  • Assessed functional maturation and responsiveness following ERRγ manipulation.

Main Results:

  • Estrogen-related receptor gamma (ERRγ) was found to promote functional maturation.
  • ERRγ enhanced glucose and hormone responsiveness in neonatal mouse beta cells.
  • ERRγ also promoted maturation in human iPSC-derived beta-like cells.

Conclusions:

  • Estrogen-related receptor gamma (ERRγ) is a key regulator of pancreatic beta cell functional maturation.
  • Targeting ERRγ may offer therapeutic strategies for improving insulin secretion and managing metabolic disorders.