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Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis
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BDNF isoforms: a round trip ticket between neurogenesis and serotonin?
Rocío Beatriz Foltran1, Silvina Laura Diaz1
1Instituto de Biología Celular y Neurociencias Prof. E. De Robertis, CONICET-UBA, Fac. de Medicina - UBA, Buenos Aires, Argentina.
Journal of Neurochemistry
|May 12, 2016
Summary
Brain-derived neurotrophic factor (BDNF) isoforms and their role in adult hippocampal neurogenesis are reviewed. Serotonergic agents modulate BDNF expression, yielding complex results requiring further research.
Area of Science:
- Neuroscience
- Molecular Biology
- Cell Biology
Background:
- Brain-derived neurotrophic factor (BDNF) is crucial for neuronal function.
- BDNF exists in two isoforms: pro-BDNF and mature BDNF.
- Understanding BDNF signaling is key to neurogenesis research.
Purpose of the Study:
- To review BDNF isoforms and their role in adult hippocampal neurogenesis.
- To analyze the modulation of BDNF expression by serotonergic agents.
- To explore recent counterintuitive findings regarding BDNF, serotonin, and neurogenesis.
Main Methods:
- Literature review of BDNF isoforms and neurogenesis.
- Analysis of studies on serotonergic modulation of BDNF.
- Synthesis of current research on the BDNF-serotonin-neurogenesis axis.
Main Results:
- BDNF isoforms (pro-BDNF and mature BDNF) have distinct roles.
- Serotonergic agents can modulate BDNF expression.
- Recent research presents complex and sometimes contradictory findings.
Conclusions:
- The interplay between BDNF, serotonin, and neurogenesis is intricate.
- Further research is needed to clarify paradoxical results.
- New hypotheses are encouraged to advance understanding of this triumvirate.
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