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Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

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Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
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Gastritis-I: Introduction and Types01:27

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Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Viral Meningitis01:18

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Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
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Reservoir of Infection01:30

Reservoir of Infection

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Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Related Experiment Video

Updated: Mar 21, 2026

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
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Another gastroenteritis?

Ewelina Biskup1, Magdalena Necek2, Qu Changjin1

  • 11 Department of Anaesthesiology and Surgical Intensive Care Unit, University Hospital of Tongji University, Yangpu Central Hospital, Shanghai, China.

Praxis
|May 12, 2016
PubMed
Summary

Portal vein thrombosis (PVT) can occur in healthy individuals due to genetic mutations causing hypercoagulable states. Early diagnosis is crucial for effective management of this rare condition.

Keywords:
Faktor V LeidenPfortaderthromboseProthrombin-Gen-MutationThrombophiliefactor V Leidenportal vein thrombosisprothrombin gene mutationrecurrent venous thromboembolismrezidivierende venöse Thromboembolienthrombophilia

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Area of Science:

  • Gastroenterology
  • Hematology
  • Internal Medicine

Background:

  • Portal vein thrombosis (PVT) is a significant cause of abdominal pain, frequently overlooked.
  • PVT is commonly associated with liver cirrhosis but can occur in healthy individuals.

Purpose of the Study:

  • To report a case of PVT in a previously healthy individual.
  • To highlight the importance of investigating underlying hypercoagulable states in unexplained PVT.

Main Methods:

  • Case report of a 42-year-old patient with persistent upper abdominal pain.
  • Review of differential diagnoses for PVT in non-cirrhotic patients.
  • Discussion of genetic factors contributing to thrombotic events.

Main Results:

  • The patient presented with symptoms suggestive of PVT.
  • The case underscores that PVT can occur in individuals without liver disease.

Conclusions:

  • Gene mutations leading to hypercoagulable states are potential causes of PVT in healthy individuals.
  • Investigating disorders like myeloproliferative neoplasm (MPN), paroxysmal nocturnal hemoglobinuria (PNH), and antiphospholipid antibody syndrome is critical for diagnosing PVT in unexplained cases.