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Updated: Mar 21, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
An antimicrobial stewardship program reduces antimicrobial therapy duration and hospital stay in surgical wards
R Güerri-Fernández1, J Villar-García, S Herrera-Fernández
1Robert Güerri Fernández, Infectious Diseases Dpt, Hospital del Mar, Paseo Marítimo 25-29, Barcelona 08003. Spain. rguerri@imim.es.
Abstract:
We report a quasi-experimental study of the implementation of an antimicrobial stewardship program in two surgical wards, with a pre-intervention period with just assessment of prescription and an intervention period with a prospective audit on antibiotic prescription model. There was a significant reduction of length of stay and the total days of antimicrobial administration. There were no differences in mortality between groups. The antimicrobial stewardship program led to the early detection of inappropriate empirical antibiotic treatment and was associated with a significant reduction in length of stay and the total duration of antimicrobial therapy.
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