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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

344
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
344
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

312
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
312
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

326
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
326
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

314
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
314
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

797
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
797
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

310
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
310

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Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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[Geriatrics - an interdisciplinary challenge].

Roland Nau1,2, Marija Djukic3, Manfred Wappler4

  • 1Geriatrisches Zentrum, Evangelisches Krankenhaus Göttingen-Weende, An der Lutter 24, 37075, Göttingen, Deutschland. rnau@gwdg.de.

Der Nervenarzt
|May 12, 2016
PubMed
Summary

Caring for elderly patients with multiple health issues requires a multidisciplinary approach. Neurologists offer expertise in complex geriatric conditions, enhancing patient autonomy and quality of life.

Keywords:
DementiaDepressionInternal medicineMedical specialitiesNeurology

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Area of Science:

  • Geriatric Medicine
  • Neurology
  • Healthcare Systems

Background:

  • Elderly patients often present with multimorbidities, significantly impacting daily functioning.
  • Geriatric care necessitates a holistic, multiprofessional team approach focused on improving functional status, quality of life, and autonomy.
  • In Germany, geriatric care involves physicians from diverse specialties, with clinical geriatrics training offering equal rights across specialties.

Purpose of the Study:

  • To discuss the evolving landscape of geriatrician qualification in Germany.
  • To highlight the crucial role of neurologists in managing complex geriatric conditions.
  • To emphasize the need for neurologists to possess general internal medicine skills for geriatric leadership roles.

Main Methods:

  • Review of current practices and training structures in geriatric care in Germany.
  • Analysis of the specific expertise neurologists bring to geriatric patient management.
  • Discussion of necessary cross-disciplinary training for neurologists in geriatrics.

Main Results:

  • Neurologists possess significant expertise in treating a wide range of neurological and pain-related conditions common in geriatric patients.
  • The current training structure allows equal rights for various specialties in clinical geriatrics.
  • A debate exists regarding whether to link geriatrician suitability to specific medical specialties.

Conclusions:

  • Multidisciplinary cooperation is vital for effective geriatric care.
  • Neurologists are well-equipped to manage complex geriatric neurological conditions.
  • Acquiring general internal medicine skills is essential for neurologists in leadership positions within geriatric departments.