Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

830
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
830
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

613
Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
613
Anxiety: Overview01:18

Anxiety: Overview

1.3K
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
1.3K
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

625
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
625

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Region- and sex-dependent single-cell transcriptomic signatures of neurons and glia in the prefrontal cortex and nucleus accumbens in a rat model of alcohol relapse.

Neuropharmacology·2026
Same author

Exploring a world turned upside down: a shift to egocentric navigation.

Scientific reports·2026
Same author

Oxa-noribogaine reduces alcohol drinking through aversion learning and by altering glutamatergic activity in the mPFC.

Research square·2026
Same author

Exposure to a high-fat diet compromises gut health, behavior, and HPA axis function, with partial reversal when limited to adolescence.

Brain research bulletin·2026
Same author

There Is No Place Like Home: Behavioral and Physical Home Traits in Humans and Other Animals.

Bioscience·2026
Same author

Methylphenidate denied access to WHO's list of essential medicines for the third time.

BMJ evidence-based medicine·2026

Related Experiment Video

Updated: Mar 21, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

16.0K

Obsessive-compulsive disorder: Insights from animal models.

Henry Szechtman1, Susanne E Ahmari2, Richard J Beninger3

  • 1Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.

Neuroscience and Biobehavioral Reviews
|May 12, 2016
PubMed
Summary

Animal models reveal how brain circuit activity drives obsessive-compulsive disorder (OCD) behaviors. This research informs new diagnostic tools and treatments for OCD and related conditions.

Keywords:
Animal modelBasal gangliaDeer mouseEndophenotypesNucleus accumbens coreObsessive-compulsive disorderOrbitofrontal cortexQuinpiroleSecurity motivation systemStriatum

More Related Videos

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
06:50

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Published on: December 24, 2013

30.3K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

2.7K

Related Experiment Videos

Last Updated: Mar 21, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

16.0K
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
06:50

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Published on: December 24, 2013

30.3K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

2.7K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • Obsessive-compulsive disorder (OCD) is a debilitating mental health condition.
  • Understanding the neurobiological underpinnings of OCD is crucial for developing effective treatments.

Purpose of the Study:

  • To explore the utility of animal models in elucidating the mechanisms of OCD.
  • To investigate the role of specific neural circuits in compulsive behaviors.
  • To assess the potential of animal models for drug discovery and diagnostic test development.

Main Methods:

  • Optogenetic manipulation of cortico-basal ganglia-thalamo-cortical (CBGTC) circuits in mice.
  • Utilizing diverse animal models, including deer mice, to study spontaneous behaviors.
  • Analyzing compulsive behavior components and comorbid psychiatric disorders in animal models.

Main Results:

  • Experimental manipulation of CBGTC circuits induced compulsive behavior in mice, suggesting a causal link.
  • Different animal models offer insights into deep brain stimulation efficacy for OCD endophenotypes.
  • Spontaneous behaviors in deer mice provide a platform for neurobiological investigation and drug testing.
  • Comorbid disorders may share neural circuits with OCD, influencing compulsive behavior.

Conclusions:

  • Animal models are valuable tools for understanding OCD neurobiology and compulsive behaviors.
  • Research supports a motivational perspective on OCD and the potential for dissecting rituals.
  • These findings pave the way for novel diagnostic approaches and therapeutic strategies for OCD.