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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents.

Gorkem Yilmaz1, Emine Guler2,3, Firat Baris Barlas2

  • 1Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469, Istanbul, Turkey.

Macromolecular Rapid Communications
|May 12, 2016
PubMed
Summary

Thioxanthone-containing polymers show promise as anticancer and radiotherapy agents. These water-soluble, biocompatible materials exhibit radiosensitizer effects and anticancer activity, making them suitable for therapeutic applications.

Keywords:
anticancercytotoxicitypoly(ethylene glycol)poly(vinyl alcohol)radiotherapythioxanthones

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Area of Science:

  • Polymer Chemistry
  • Medicinal Chemistry
  • Biotechnology

Background:

  • Thioxanthone (TX) derivatives are established photoinitiators with emerging biological applications.
  • Anticancer properties of thioxanthones are a recent and significant discovery.
  • Polymer-supported thioxanthones offer enhanced utility in biomedical fields.

Purpose of the Study:

  • To synthesize and evaluate water-soluble polymers functionalized with thioxanthone moieties.
  • To investigate the potential of these novel polymers as anticancer and radiotherapy agents.
  • To assess the biocompatibility, stability, and therapeutic efficacy of the developed polymeric materials.

Main Methods:

  • Preparation of poly(vinyl alcohol) and poly(ethylene glycol) with pendant and end-chain thioxanthone groups.
  • Evaluation of water-solubility, biocompatibility, and stability of the synthesized polymers.
  • Assessment of radiosensitizer effects and in vitro anticancer activity.

Main Results:

  • Successfully synthesized water-soluble, biocompatible polymers incorporating thioxanthone (TX) moieties.
  • Demonstrated significant radiosensitizer effects for both polymer types.
  • Confirmed notable anticancer activity of the thioxanthone-functionalized polymers in a polymeric scaffold.

Conclusions:

  • The developed thioxanthone-containing polymers are promising candidates for therapeutic applications.
  • These polymers exhibit favorable characteristics including water-solubility, radiosensitizing ability, and anticancer efficacy.
  • Polymeric scaffolds offer a viable platform for enhancing the therapeutic potential of thioxanthone derivatives.