Related Experiment Video
Updated: Mar 21, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Triazolyl-Based Molecular Gels as Ligands for Autocatalytic 'Click' Reactions
Marco Araújo1, Santiago Díaz-Oltra1, Beatriu Escuder2
1Departament de Química Inorgànica i Orgànica, Universitat Jaume I, 12071, Castelló, Spain.
Abstract:
The catalytic performance of triazolyl-based molecular gels was investigated in the Huisgen 1,3-dipolar cycloaddition of alkynes and azides. Low-molecular-weight gelators derived from l-valine were synthesized and functionalized with a triazole fragment. The resultant compounds formed gels either with or without copper, in a variety of solvents of different polarity. The gelators coordinated Cu(I) and exhibited a high catalytic activity in the gel phase for the model reaction between phenylacetylene and benzylazide. Additionally, the gels were able to participate in autocatalytic synthesis and the influence of small structural changes on their performance was observed.
Related Concept Videos
Ziegler–Natta Chain-Growth Polymerization: Overview
EDTA: Chemistry and Properties
Complexometric Titration: Ligands
Cycloaddition Reactions: MO Requirements for Thermal Activation

