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Related Concept Videos

Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Related Experiment Video

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Spontaneous Murine Model of Anaplastic Thyroid Cancer
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Thyroid Cancer and Tumor Collaborative Registry (TCCR).

Oleg Shats1, Whitney Goldner2, Jianmin Feng3

  • 1Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE, USA.; Progenomix, Inc., Omaha, NE, USA.

Cancer Informatics
|May 12, 2016
PubMed
Summary

The Thyroid Cancer and Tumor Collaborative Registry (TCCR) securely manages patient data and biospecimens. This system supports the development of new diagnostic, prevention, treatment, and survivorship strategies for thyroid cancer.

Keywords:
biomedical informaticsmetadataregistrysoftwarestandardizationthyroid cancer

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Area of Science:

  • Oncology
  • Bioinformatics
  • Data Management

Background:

  • Thyroid cancer (TC) and thyroid nodules (TN) require robust data collection for research.
  • Existing systems may lack comprehensive data integration and biobanking capabilities.
  • Need for a secure, sustainable platform for managing TC/TN patient data and biospecimens.

Purpose of the Study:

  • To describe the development and capabilities of the Thyroid Cancer and Tumor Collaborative Registry (TCCR).
  • To highlight the integration of a biobank management system (OpenSpecimen) for biospecimen annotation.
  • To showcase the system's technical and organizational framework for data collection and management.

Main Methods:

  • Web-based registry (TCCR) coupled with OpenSpecimen for biobanking.
  • Collection of demographic, lifestyle, clinical, and quality of life data.
  • Implementation of metadata-driven architecture, data sharing standards, Agile methodology, SaaS, and confederation model.

Main Results:

  • The TCCR successfully collects and manages diverse data for TC and TN patients.
  • The system integrates biospecimen data through OpenSpecimen.
  • Currently contains data on 2,261 subjects and over 28,000 biospecimens.

Conclusions:

  • The TCCR provides a secure, reliable, user-friendly, and self-sustainable system for TC and TN data.
  • The registry is adaptable and compatible with various devices and evolving environments.
  • Collected data and samples are crucial for advancing diagnostic, prevention, treatment, and survivorship strategies for TC.