Related Experiment Video
Updated: Mar 21, 2026

18:11
Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
Published on: October 1, 2007
21.9K
Configurable NOR gate arrays from Belousov-Zhabotinsky micro-droplets.
A L Wang1, J M Gold1, N Tompkins1
1Department of Physics, Brandeis University, Waltham, MA 02453, USA.
Summary
Researchers created a chemical NOR gate using the Belousov-Zhabotinsky (BZ) reaction. This study demonstrates computation using coupled chemical oscillators, paving the way for novel bio-computing applications.
Area of Science:
- Chemical Oscillations and Reactions
- Biochemical Computation
- Microfluidics
Background:
- The Belousov-Zhabotinsky (BZ) reaction is a classic example of a chemical oscillator exhibiting complex dynamic behavior.
- Chemical oscillators offer potential for developing novel computational systems beyond traditional electronics.
- Coupling of chemical oscillators via inhibition is a key mechanism for information processing.
Purpose of the Study:
- To establish a basis for computation using chemical oscillators.
- To investigate the Belousov-Zhabotinsky reaction for creating logic gates.
- To demonstrate the feasibility of using coupled chemical oscillators for computational tasks.
Main Methods:
- Utilized BZ reaction droplets suspended in oil for the experimental setup.
- Employed bromine (Br2) as the inhibitory coupling agent between droplets.
- Arranged three droplets linearly to function as a NOR gate, with two inputs and one output.
Main Results:
- Successfully implemented a chemical NOR gate using the BZ reaction system.
- Input oxidation spikes (TRUE) reliably caused a delay in the output spike (FALSE).
- Absence of input spikes (FALSE) resulted in an immediate output spike (TRUE), demonstrating NOR gate functionality.
Conclusions:
- Microfluidic experiments reliably produced chemical NOR gates with predictable behavior.
- This work provides a foundation for developing chemical-based computing systems.
- BZ reaction oscillators can be harnessed for information processing and logic operations.

