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Blood coagulation changes in rats during development of epithelioma
R Tomasiuk1, H Gawlowska, B Sawicka
1Medical Academy, Institute of Environmental Research and Bioanalysis, Department of Biochemistry, Lódź, Poland.
Neoplasma
|January 1, 1989
Abstract:
Coagulation activity in the blood of rats during the development of Guerin epithelioma was studied. Clotting time, level of fibrinogen and some coagulation factors (II, V, VII + X) in the plasma were determined and thromboelastographic studies were performed. Two periods of blood hypercoagulability were observed in the process of epithelioma development. The first a short-term period, was noticed during the first days following the implantation of the neoplastic tissue. The second took place during the intensive growth of the primary tumor and metastases.