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Quantitative evaluation of pontine atrophy using computer tomography.

K Chida1, N Goto, I Kamikura

  • 1Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.

Neuroradiology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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This study established normal pontine volume at approximately 19 cm3 using computer tomography (CT) and autopsy. Pontine atrophy is defined as a volume less than 12 cm3, providing a new diagnostic threshold.

Area of Science:

  • Neuroanatomy
  • Radiology
  • Neuropathology

Background:

  • Accurate measurement of pontine volume is crucial for diagnosing neurological conditions.
  • Previous studies have lacked standardized methods for determining normal pontine volume and atrophy thresholds.

Purpose of the Study:

  • To establish normative values for pontine volume in healthy adults.
  • To define a quantitative threshold for identifying pontine atrophy.

Main Methods:

  • Pontine volume was assessed in 37 healthy adults using computer tomography (CT) with 5 mm and 2 mm slices.
  • Pontine volume was also measured in 29 autopsied brains without neurological disease, using serial 5 mm slices.
  • Pontine areas were measured with an image analyzer, and volume was calculated from mean area and cranio-caudal length.

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Main Results:

  • The average pontine volume was determined to be approximately 19 cm3 across both CT and autopsy methods.
  • A pontine volume below 12 cm3 (mean - 2 SD) was identified as indicative of pontine atrophy.
  • These findings provide a novel, quantitative definition for pontine atrophy.

Conclusions:

  • Normal pontine volume in healthy adults is approximately 19 cm3.
  • A threshold of less than 12 cm3 reliably indicates pontine atrophy.
  • These quantitative measures offer valuable diagnostic criteria for neurological assessments involving the pons.