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Updated: Mar 21, 2026
07:27
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
Published on: October 21, 2017
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Liver Cirrhosis and Kidney
1Medizinische Klinik II, Klinikum der Universität München, München, Germany.
Digestive Diseases (Basel, Switzerland)
|May 13, 2016
Summary
Renal failure in cirrhosis is often linked to reduced blood volume, impacting kidney function and ascites. Guidelines recommend albumin infusions for paracentesis, while acute kidney injury (AKI) in cirrhosis is increasingly recognized for its prognostic significance.
Area of Science:
- Hepatology
- Nephrology
- Internal Medicine
Background:
- Renal failure in cirrhosis presents diverse etiologies.
- Established treatments exist for hepatorenal syndrome and ascites.
- Acute kidney injury (AKI) in cirrhosis is a growing area of clinical focus.
Purpose of the Study:
- To review the pathophysiology and management of renal complications in liver cirrhosis.
- To highlight the significance of acute kidney injury (AKI) in cirrhotic patients.
- To discuss current therapeutic strategies and emerging clinical relevance.
Main Methods:
- Literature review focusing on renal failure in cirrhosis.
- Analysis of pathophysiological mechanisms, including central blood volume reduction.
- Evaluation of treatment guidelines and controversial therapeutic roles.
Main Results:
- Reduced effective blood volume is central to renal failure and ascites in cirrhosis.
- Albumin infusion post-paracentesis is a guideline-recommended therapy.
- Transjugular intrahepatic portosystemic shunt (TIPS) shows promise for ascites control and survival.
Conclusions:
- Albumin infusion is crucial for managing ascites and preventing renal complications.
- The role of beta-blockers in cirrhotic patients with ascites remains debated.
- Redefined criteria for AKI in cirrhosis underscore its prognostic importance.
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