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Mammalian mitochondrial ribosomal small subunit (MRPS) genes: A putative role in human disease

Gopal Gopisetty1, Rajkumar Thangarajan1

  • 1Department of Molecular Oncology, Cancer Institute (WIA), Chennai, India.

Gene
|May 13, 2016
PubMed

Insights

Mitochondrial ribosomal small subunit (MRPS) gene expression is altered in various human diseases, suggesting their involvement in disease development. This review examines MRPS genes and their expression patterns.

Area of Science:

  • Cell Biology
  • Genetics
  • Molecular Biology

Background:

  • Mitochondria, known as cellular powerhouses, are crucial for ATP production.
  • Beyond energy, mitochondria regulate apoptosis and autophagy; dysregulation leads to pathology.
  • Mitochondria contain ~1500 proteins, mostly encoded by nuclear genes, synthesized by mitochondrial ribosomes (mitoribosomes).

Purpose of the Study:

  • To review mitochondrial ribosomal small subunit (MRPS) genes.
  • To analyze MRPS gene and protein expression data from public databases.
  • To investigate the role of MRPS gene expression aberrations in human diseases.

Main Methods:

  • Literature review of MRPS genes.
  • Analysis of publicly available gene and protein expression databases.
  • Survey of expression patterns in various human diseases.

Main Results:

  • The human mitochondrial ribosomal protein (MRP) gene family includes 30 genes for the small subunit.
  • Aberrations in MRPS gene expression patterns were observed across diverse human diseases.
  • These findings suggest a potential role for MRPS genes in disease etiology.

Conclusions:

  • Mitochondrial ribosomal small subunit genes are implicated in the pathogenesis of various human diseases.
  • Altered MRPS gene expression highlights their importance beyond basic mitochondrial function.
  • Further research into MRPS genes could reveal new therapeutic targets for disease.
Keywords:
DiseaseGenesMitochondriaRibosomesSmall subunit

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