The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium

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Monica Benvenuto1, Rosanna Mattera2, Gloria Taffera3

  • 1Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome 00133, Italy. monicab4@hotmail.it.

Nutrients
|May 13, 2016
PubMed

Insights

Dietary polyphenols show promise in preventing and treating malignant mesothelioma (MM). These compounds combat cancer by reducing inflammation and modulating immune responses, offering a potential therapeutic strategy against asbestos-induced tumors.

Area of Science:

  • Oncology
  • Immunology
  • Toxicology

Background:

  • Malignant mesothelioma (MM) is a serious cancer linked to asbestos exposure.
  • Chronic inflammation and immune system deregulation play critical roles in MM development and progression.
  • Targeting signaling pathways and inflammation is crucial for MM therapy.

Purpose of the Study:

  • To review the current knowledge on polyphenols' effects on malignant mesothelioma.
  • To explore the potential of dietary polyphenols in MM therapy and prevention.
  • To highlight how polyphenols modulate inflammation and immune responses in MM.

Main Methods:

  • Literature review of studies on polyphenols, inflammation, and MM.
  • Analysis of mechanisms by which polyphenols affect cancer cell growth.
  • Examination of polyphenol interactions with signaling pathways and immune cells.

Main Results:

  • Dietary polyphenols inhibit MM cell growth by targeting multiple signaling pathways.
  • Polyphenols reduce inflammation and modulate immune responses, crucial for MM.
  • Polyphenols can target reactive oxygen species (ROS) and pro-inflammatory molecules.

Conclusions:

  • Polyphenols represent a promising tool for preventing and counteracting malignant mesothelioma growth.
  • Modulating inflammation and immune responses are key mechanisms for polyphenol efficacy in MM.
  • Further research into polyphenol-based MM therapies is warranted.
Keywords:
ROS and RNSasbestosimmune systeminflammationmalignant mesotheliomapolyphenols

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