Related Experiment Video
Updated: Mar 21, 2026
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Orbital Paraganglioma and Succinate Dehydrogenase Staining for Genetic Testing Triage and Prognosis
1Department of Anatomical Pathology, St Vincent's Hospital, Melbourne. Vic., Australia.
Purpose Of The Study:
To describe the rare occurrence of a paraganglioma in the orbit and how to triage for genetic testing and assess the prognosis with succinate dehydrogenase subunit B (SDHB) immunohistochemical staining.
Method:
Case report.
Procedures:
A 47-year-old 'healthy' male presented with painless exophthalmos and diplopia secondary to an infraorbital tumour mass.
Results:
The orbital biopsy was diagnosed as paraganglioma with positive staining with SDHB.
Conclusion:
The rarity of an orbital paraganglioma was followed by the clinical search for a possible occult extraorbital primary paraganglioma. SDHB staining helped in the triage for genetic testing and gave an idea about the prognosis for this tumour.
