Cholesteryl ester transfer protein inhibitors: challenges and perspectives
T D Filippatos1, E Klouras1, F Barkas1
1a Department of Internal Medicine, School of Medicine , University of Ioannina , Ioannina , Greece.
Expert Review of Cardiovascular Therapy
|May 13, 2016
Summary
Cholesteryl ester transfer protein (CETP) inhibitors raise HDL-C but have faced challenges. Newer CETP inhibitors show promise for lipid profiles, but cardiovascular outcomes require further study.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Lipid Metabolism
Background:
- Cholesteryl ester transfer protein (CETP) inhibitors increase high-density lipoprotein cholesterol (HDL-C).
- Potential benefits for cardiovascular disease risk reduction are being investigated.
Purpose of the Study:
- To review current data on CETP inhibitors' effects on cardiovascular disease risk.
- To examine mechanisms of action and safety profiles of CETP inhibitors.
Main Methods:
- Review of existing clinical data and trial outcomes for various CETP inhibitors.
- Analysis of lipid profiles, cardiovascular events, and adverse effects.
Main Results:
- Torcetrapib was discontinued due to adverse effects like increased blood pressure.
- Dalcetrapib and evacetrapib were terminated due to lack of efficacy in cardiovascular outcomes.
- Anacetrapib and TA-8995 show positive effects on lipid profiles (increased HDL-C, reduced LDL-C and Lp(a)).
Conclusions:
- Some adverse effects of CETP inhibitors may be class-specific.
- Newer CETP inhibitors demonstrate improved lipid profiles but require large outcome trials for confirmation of cardiovascular benefits and safety.
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