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Synthesis of sp(3)-rich scaffolds for molecular libraries through complexity-generating cascade reactions
1Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. ten@kemi.dtu.dk mhc@kemi.dtu.dk.
Organic & Biomolecular Chemistry
|May 13, 2016
Abstract:
An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented. Key steps of the strategy include tandem Petasis and Diels-Alder reactions, and divergent complexity-generating cyclization cascades from a key dialdehyde intermediate. The methodology is validated through the synthesis of a representative compound set, which has been used in the production of 1617 molecules for the European Lead Factory.

