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G-Quadruplex Supramolecular Assemblies in Photochemical Upconversion.

Saymore Mutsamwira1, Eric W Ainscough1, Ashton C Partridge1,2

  • 1Institute of Fundamental Sciences, Massey University, Private Bag 11 222, Palmerston North, 4442, New Zealand.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 13, 2016
PubMed
Summary

Researchers synthesized G-quadruplex (G4) DNA with a TINA molecule for photochemical upconversion (PUC). Attaching TINA to G4-DNA enabled efficient green-to-blue PUC, demonstrating DNA

Keywords:
G4-DNAenergy upconversionfluorescencepyrenetriplet-triplet annihilation

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Area of Science:

  • Supramolecular Chemistry
  • Photochemistry
  • Biophysics

Background:

  • G-quadruplex (G4) DNA structures offer unique scaffolds for molecular assemblies.
  • Photochemical upconversion (PUC) is an energy conversion process with potential applications in artificial photosynthesis.
  • Integrating G4 DNA with chromophores can lead to novel light-harvesting systems.

Purpose of the Study:

  • To synthesize and characterize G4 DNA modified with a TINA monomer.
  • To investigate the photochemical properties of G4 DNA-chromophore complexes.
  • To explore the potential of G4 DNA in DNA-based assemblies for photochemical upconversion.

Main Methods:

  • Synthesis of tetramolecular G-quadruplex DNA with a covalently attached TINA monomer.
  • Complexation with tris(2,2'-bipyridine)ruthenium(II) ([Ru(bpy)3 ](2+)) and ZnTMpyP4.
  • Spectroscopic analysis including UV/Vis, fluorescence, and circular dichroism (CD).

Main Results:

  • Successful synthesis of G4 DNA with TINA monomer.
  • Demonstrated communication between DNA-bound ligands and the TINA molecule.
  • Observed green-to-blue photochemical upconversion (PUC) with a specific G4-DNA-TINA construct.

Conclusions:

  • G4 DNA can serve as a template for DNA-based assemblies for PUC.
  • The attachment strategy of chromophores to DNA is critical for PUC efficiency.
  • This work highlights the potential of G4 DNA in creating artificial photosynthetic centers.