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Updated: Mar 21, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.2K

[HOMOCYSTEINE AS A PROGNOSTIC MARKER OF ATRIAL REMODELING AND CLINICAL PICTURE IN PATIENTS WITH PAROXYSMAL AND

V A Snezhitsky, E S Yatskevich, E M Doroshenko

    Klinicheskaia Meditsina
    |May 14, 2016
    PubMed

    Insights

    High homocysteine levels (over 11 mcmol/l) are linked to left ventricle enlargement and increased atrial fibrillation (AF) relapse rates. This suggests homocysteine influences atrial remodeling, serving as a prognostic factor for AF recurrence.

    Area of Science:

    • Cardiology
    • Biochemistry

    Context:

    • Atrial fibrillation (AF) poses significant clinical challenges, particularly in patients with co-existing coronary heart disease and hypertensive disease.
    • Understanding the factors influencing AF recurrence and atrial remodeling is crucial for improving patient outcomes.

    Purpose:

    • To investigate the prognostic significance of serum homocysteine levels in relation to atrial remodeling and clinical outcomes in patients with paroxysmal and persistent atrial fibrillation.
    • To determine if elevated homocysteine levels correlate with left ventricle enlargement and AF relapse rates.

    Summary:

    • This study analyzed 75 patients with AF and cardiovascular comorbidities, comparing them to 19 controls without AF.
    • Echocardiography assessed cardiac structure and function, while homocysteine levels and AF relapse rates were monitored over one year.
    • A homocysteine level exceeding 11.2 mcmol/l was associated with left ventricle enlargement ( > 40 mm) and a higher frequency of AF relapses.

    Impact:

    • The findings suggest a strong relationship between homocysteine levels, left ventricle dimensions, and AF recurrence, indicating homocysteine's role in atrial remodeling.
    • Elevated homocysteine ( > 11 mcmol/l) should be considered a valuable prognostic marker for predicting increased AF relapse rates.

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