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Updated: Mar 21, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
IL-17+ CD8+ T cells: Differentiation, phenotype and role in inflammatory disease
Ushani Srenathan1, Kathryn Steel1, Leonie S Taams1
1Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection & Inflammatory Disease, King's College London, London, UK.
Abstract:
The pro-inflammatory cytokine interleukin-17A (IL-17) has been the subject of research by many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ T cells (the so-called Th17 cells); however various other immune cell subsets can also synthesise and express IL-17, including CD8+ T cells. Here we review recent data regarding the presence of IL-17+ CD8+ T cells (also known as Tc17 cells) in human inflammatory disease, discuss current knowledge regarding the culture conditions required for the differentiation of these cells in humans and mice, and describe key phenotypic and functional features. Collectively, this information may shed light on the potential pathogenic role that IL-17+ CD8+ T cells may play in human inflammatory disease.
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