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Sheep YAP1 temporal and spatial expression trend and its relation with MyHCs expression.

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Yes-associated protein 1 (YAP1) influences sheep muscle fiber development. Its expression correlates with myosin heavy chain (MyHC) types, offering genetic insights for improving sheep muscle growth.

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Area of Science:

  • Animal Science
  • Molecular Biology
  • Muscle Physiology

Background:

  • Myosin heavy chain (MyHC) isoforms determine skeletal muscle fiber characteristics.
  • Yes-associated protein 1 (YAP1) is a key regulator of cell proliferation and differentiation.

Purpose of the Study:

  • To investigate the temporal and spatial expression patterns of YAP1 and MyHC in Hu Sheep skeletal muscles.
  • To explore the relationship between YAP1 expression and MyHC isoforms during sheep growth.

Main Methods:

  • Real-time quantitative PCR (RT-PCR) was employed to analyze gene expression.
  • Expression levels were studied across four distinct skeletal muscles and three developmental stages.

Main Results:

  • YAP1 expression varied across muscle types and increased with age, with highest levels in gastrocnemius and lowest in longissimus dorsi.
  • MyHC isoform expression differed by muscle type and developmental stage; MyHCIIX increased with age, while MyHCI and MyHCIIA decreased.
  • YAP1 expression showed a negative correlation with MyHCII and a positive correlation with MyHCIIX.

Conclusions:

  • YAP1 expression significantly impacts sheep skeletal muscle fiber development post-birth.
  • Findings provide valuable genetic information for selecting candidate genes to enhance sheep muscle growth.