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Association between RASSF1A promoter methylation and renal cell cancer susceptibility: a meta-analysis

Y Q Huang1,2,3, H Guan1,2,3, C H Liu1,2,3

  • 1Department of Urology, Affiliated Zhongda Hospital, Medical School, Southeast University, Nanjing, China.

Genetics and Molecular Research : GMR
|May 14, 2016
PubMed

Insights

Epigenetic silencing of the Ras-associated domain family 1A (RASSF1A) gene through promoter hyper-methylation is linked to increased renal cell cancer risk. This methylation also correlates with higher tumor grade, suggesting its potential in predicting cancer prognosis.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Ras-associated domain family 1A (RASSF1A) gene silencing via promoter hyper-methylation is implicated in various cancers.
  • The specific role of RASSF1A promoter methylation in renal cancer remains underexplored.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between RASSF1A promoter methylation and renal cell cancer risk.
  • To investigate the correlation between RASSF1A promoter methylation and clinical/pathological variables in renal cancer.

Main Methods:

  • A meta-analysis was performed on 13 published studies.
  • Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated to assess the association between RASSF1A promoter methylation and renal cell cancer risk and clinicopathological features.

Main Results:

  • RASSF1A promoter methylation was significantly associated with an increased risk of renal cell cancer (OR = 19.35).
  • A significant positive correlation was found between RASSF1A promoter methylation and pathological tumor grade (OR = 3.32).
  • A potential positive correlation was observed between RASSF1A promoter methylation and tumor stage (OR = 1.89, P = 0.051).

Conclusions:

  • RASSF1A promoter methylation is a significant risk factor for renal cell cancer.
  • RASSF1A promoter methylation correlates with higher pathological tumor grade.
  • RASSF1A promoter methylation may serve as a predictive biomarker for renal cell cancer prognosis.

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