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Distribution and Trends of Human Parainfluenza Viruses in Hospitalised Children

M Anjaneya Swamy1, Bharti Malhotra2, P V Janardhan Reddy1

  • 1Department of Microbiology & Immunology, Advanced Basic Sciences & Clinical Research Laboratory, (ICMR Grade - I Viral Diagnostics & Research Laboratory), Sawai Man Singh Medical College, Jawahar Lal Nehru Marg, Jaipur, 302004, Rajasthan, India.

Indian Journal of Pediatrics
|May 14, 2016
PubMed

Insights

Human Parainfluenza viruses (HPIV) 1-4 circulate year-round in hospitalized children under five in Jaipur. HPIV-3 was most common, with over 30% of cases showing co-infections with other respiratory viruses.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Respiratory Illnesses

Background:

  • Human Parainfluenza viruses (HPIV) are significant causes of respiratory illness in young children.
  • Understanding the epidemiology of HPIV types and co-infections is crucial for public health interventions.

Purpose of the Study:

  • To determine the distribution and trends of HPIV types 1-4 in hospitalized children aged 5 years and younger.
  • To investigate co-infections with other respiratory viruses in this pediatric population.

Main Methods:

  • Nucleic acid was extracted from nasopharyngeal aspirates and throat swabs of 743 children.
  • Real-time RT-PCR was employed to detect HPIV types 1-4 and other respiratory viruses.

Main Results:

  • Overall HPIV positivity was 9.28% (69/743), with HPIV-3 being the most prevalent (5.52%).
  • Maximum positivity occurred in children aged 13-36 months.
  • Co-infections with other respiratory viruses were detected in 31.88% of HPIV-positive patients.

Conclusions:

  • All four HPIV types circulate in Jaipur children, with peak incidence during post-monsoon and winter seasons.
  • The findings support the need for targeted HPIV vaccination strategies for all types.
Abstract

Keywords:
Human parainfluenza viruses 1–4Real time RT-PCRSeasonal trends

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