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Related Experiment Video

Updated: Mar 21, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

Developmental programming, adiposity, and reproduction in ruminants.

M E Symonds¹, N Dellschaft¹, M Pope¹

¹Early Life Research Unit, Academic Division of Child Health, Obstetrics & Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham, UK.

|May 14, 2016

Summary

This summary is machine-generated.

Sheep studies show nutritional programming effects on offspring are modest. Factors like twin vs. singleton status and sex influence adipose tissue development and heat generation, impacting long-term outcomes.

Keywords:

Adipose tissue Leptin Perinatal growth Pregnancy

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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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Published on: June 3, 2016

Area of Science:

Reproductive biology
Developmental programming
Animal models

Background:

Sheep are used to study maternal nutrition effects on offspring. Modest programming effects observed may stem from variations in twin/singleton numbers and sex distribution.
Placental growth disparities in singleton versus twin pregnancies affect fetal body composition, particularly adipose tissue distribution and function.

Purpose of the Study:

To investigate the influence of fetal number and sex on adipose tissue development and programming in sheep.
To understand how maternal nutrition timing interacts with fetal development, considering variations in pregnancy type and offspring sex.

Main Methods:

Analysis of fetal adipose tissue depots (perirenal, pericardial, sternal/neck) in sheep under varying maternal nutritional conditions.
Measurement of leptin levels in mothers and fetuses, and assessment of brown adipose tissue-specific uncoupling protein 1 expression postnatally.

Main Results:

Fetal adipose tissue response to maternal undernutrition varies by depot, with pericardial depots being more sensitive.
Postnatal leptin levels are higher in female sheep than males, despite similar adiposity, with specific depots retaining uncoupling protein 1.

Conclusions:

Fetal number and sex are critical factors influencing adipose tissue programming in utero.
Future research must account for these variables to elucidate mechanisms of developmental programming affecting adipose and related tissues.