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Sustained Anti-inflammatory Effect of Resveratrol-Phospholipid Complex Embedded Polymeric Patch
Bhupen Kalita1,2, Malay K Das3, Munmun Sarma4
1Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, 781017, India. bhupenkalita7@gmail.com.
AAPS Pharmscitech
|May 14, 2016
Summary
Resveratrol-phospholipid complex (Phytosome®) patches offer enhanced solubility and permeability for sustained dermal anti-inflammatory treatment. These safe, stable patches demonstrate superior efficacy compared to conventional gels.
Area of Science:
- Pharmacology
- Materials Science
- Dermatology
Background:
- Free resveratrol (RSV) exhibits poor aqueous solubility and permeability, limiting its therapeutic applications.
- Resveratrol-phospholipid complex (Phytosome®) (RSVP) enhances RSV's solubility and permeability.
- Polymeric patches offer a promising drug delivery system for sustained topical treatment.
Purpose of the Study:
- To develop and characterize resveratrol-phospholipid complex (Phytosome®) polymeric patches for sustained dermal drug delivery.
- To evaluate the physicochemical properties, drug release, and skin permeation of the developed patches.
- To assess the in vivo anti-inflammatory efficacy and safety of the RSVP patches.
Main Methods:
- Resveratrol-phospholipid complex (Phytosome®) was prepared and incorporated into Eudragit RL 100, PVP K30, and PEG 400 polymeric patches via solvent casting.
- Patches were characterized for physicochemical properties, surface morphology (SEM, TEM), and component compatibility (FT-IR, DSC).
- In vitro drug release, ex vivo skin permeation, in vivo anti-inflammatory activity (carrageenan-induced paw edema), and skin irritation tests were performed.
Main Results:
- The optimized RSVP patch (F9) exhibited high drug release (95.79%) and significant skin permeation (51.36%) over 24 hours.
- FE-SEM confirmed the stability of RSVPs within the polymeric matrix after prolonged exposure.
- The RSVP patches demonstrated superior anti-inflammatory activity (84.10% inhibition) compared to diclofenac sodium gel (39.58%) and were found to be safe with no skin irritation.
Conclusions:
- Resveratrol-phospholipid complex (Phytosome®) polymeric patches provide a stable and effective system for sustained dermal delivery of resveratrol.
- These patches show significant potential for treating acute and chronic inflammatory conditions with improved efficacy and safety.
- The developed patches enable targeted drug delivery to the dermis, ensuring a prolonged therapeutic effect.
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